Andrea White

Dr. Andrea K. White

Assistant Professor
Dept. of Biological Sciences
California State University, Chico

email: akwhite@csuchico.edu
phone: (530) 898-4123
office hours:
  TTH 9:30-11:30, F 9:30-10:30



aepn plates
Education:
Ph. D. Microbiology, 2003, University of Illinois, Urbana
M. S.  Microbiology, 2000, University of Illinois, Urbana
B. A. Biology, 1997, California State University, Chico
Courses Taught:
Fall Semester: General Microbiology, Advanced Molecular Biology
Spring Semester: Bacterial Physiology, Allied Microbiology Laboratory
Research Interests:
Phosphorus cycling in the environment has long been accepted to consist only of the movement of organic and inorganic phosphates through the biosphere. However, due to the discovery of numerous environmental bacteria that are capable of performing the oxidation of reduced phosphorus compounds for use as a sole phosphorus source, and of the reduction of phosphorus in the biosynthesis of reduced phosphorus antibiotics, it is clear that P cycling and biochemistry are more complex than previously believed.  Bacterial-mediated oxidation and reduction of this essential element does indeed seem to occur, yet little is known of these processes. I am interested in understanding the mechanisms of bacterial oxidation of reduced P compounds by environmental bacteria and in investigating how these processes affect P bioavailability and bacterial communities.
 
Current Research:
Undergraduate students have recently isolated three previously uncharacterized bacterial isolates that grow on hypophosphite as the sole source of phosphorus, and therefore must be able to oxidize this compound to the required phosphate. We are currently characterizing hypophosphite oxidation pathways in these bacteria.


Publications:

White, A. K. and . W. Metcalf. 2007. Microbial metabolism of reduced phosphorus compounds. Annu. Rev. Microbiol. 61: Epub ahead of print.

White, A. K., J. A. Hoch, M. Grynberg, A. Godzik, and M. Perego. 2006. Sensor domains encoded in Bacillus anthracis virulence plasmids prevent sporulation by hijacking a sporulation sensor histidine  kinase. J. Bacteriol. 188 (17): 6354-6360.

White, A. K., and W. W. Metcalf. 2004. Two C-P lyase operons in Pseudomonas stutzeri WM88 and their roles in the oxidation of phosphonates, phosphite and hypophosphite. J. Bacteriol. 186(14): 4730-4739.

White, A. K., and W. W. Metcalf. 2004. The htx and ptx operons of Pseudomonas stutzeri WM88 are new members of the PHO regulon. J. Bacteriol.
186(17): 5876-5882.

White, A. K., and W.W. Metcalf. 2002. Isolation and biochemical characterization of hypophosphite/2-oxoglutarate dioxygenase: a novel phosphorus-oxidizing enzyme from Pseudomonas stutzeri WM88. J. Biol. Chem. 277(41): 38262-38271.

Vrtis, J. M., A. K. White, W. W. Metcalf, and W. A. van der Donk. 2002. Phosphite dehydrogenase; a versatile cofactor-regeneration enzyme. Angew. Chem. Int. Ed. 41(7): 3257-3259.

Vrtis J. M., A. K. White, W. W. Metcalf, W. A. van der Donk. 2001. Phosphite dehydrogenase: an unusual phosphoryl transfer reaction. J. Am. Chem. Soc. 123(11): 2672-3.

Costas, A.M., A. K. White, and W. W. Metcalf. 2001. Purification and characterization of a novel phosphorus-oxidizing enzyme from Pseudomonas stutzeri WM88. J. Biol. Chem. 276(20): 17429-36.