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Dr. Andrea K. White Assistant Professor Dept. of Biological Sciences California State University, Chico email: akwhite@csuchico.edu phone: (530) 898-4123 office hours: TTH 9:30-11:30, F 9:30-10:30 |
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| Education: Ph. D. Microbiology, 2003, University of Illinois, Urbana M. S. Microbiology, 2000, University of Illinois, Urbana B. A. Biology, 1997, California State University, Chico |
| Courses
Taught: Fall Semester: General Microbiology, Advanced Molecular Biology Spring Semester: Bacterial Physiology, Allied Microbiology Laboratory |
| Research
Interests: Phosphorus
cycling in the environment has long been
accepted to consist only of the movement of organic and inorganic
phosphates through the biosphere. However, due to the discovery of
numerous environmental bacteria that are capable of
performing the oxidation of reduced phosphorus compounds for use as
a sole phosphorus source, and of the reduction of phosphorus in the
biosynthesis of reduced phosphorus antibiotics, it is clear that P
cycling and biochemistry are more complex than previously
believed. Bacterial-mediated oxidation and reduction of this
essential element does
indeed seem to occur, yet little is known of these processes. I am
interested in understanding the mechanisms of bacterial oxidation of
reduced P compounds by environmental bacteria and in investigating how
these processes affect P
bioavailability and bacterial communities.
Current Research: Undergraduate students have recently isolated three previously uncharacterized bacterial isolates that grow on hypophosphite as the sole source of phosphorus, and therefore must be able to oxidize this compound to the required phosphate. We are currently characterizing hypophosphite oxidation pathways in these bacteria. |
| Publications: White, A. K. and . W. Metcalf. 2007. Microbial metabolism of reduced phosphorus compounds. Annu. Rev. Microbiol. 61: Epub ahead of print. White, A. K., J. A. Hoch, M. Grynberg, A. Godzik, and M. Perego. 2006. Sensor domains encoded in Bacillus anthracis virulence plasmids prevent sporulation by hijacking a sporulation sensor histidine kinase. J. Bacteriol. 188 (17): 6354-6360. White, A. K., and W. W. Metcalf. 2004. Two C-P lyase operons in Pseudomonas stutzeri WM88 and their roles in the oxidation of phosphonates, phosphite and hypophosphite. J. Bacteriol. 186(14): 4730-4739. White, A. K., and W. W. Metcalf. 2004. The htx and ptx operons of Pseudomonas stutzeri WM88 are new members of the PHO regulon. J. Bacteriol. 186(17): 5876-5882. White, A. K., and W.W. Metcalf. 2002. Isolation and biochemical characterization of hypophosphite/2-oxoglutarate dioxygenase: a novel phosphorus-oxidizing enzyme from Pseudomonas stutzeri WM88. J. Biol. Chem. 277(41): 38262-38271. Vrtis, J. M., A. K. White, W. W. Metcalf, and W. A. van der Donk. 2002. Phosphite dehydrogenase; a versatile cofactor-regeneration enzyme. Angew. Chem. Int. Ed. 41(7): 3257-3259. Vrtis J. M., A. K. White, W. W. Metcalf, W. A. van der Donk. 2001. Phosphite dehydrogenase: an unusual phosphoryl transfer reaction. J. Am. Chem. Soc. 123(11): 2672-3. Costas, A.M., A. K. White, and W. W. Metcalf. 2001. Purification and characterization of a novel phosphorus-oxidizing enzyme from Pseudomonas stutzeri WM88. J. Biol. Chem. 276(20): 17429-36. |